Expression of epidermal growth factor and epidermal growth factor receptor in rat periodontal tissues during orthodontic tooth movement / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 294-296, 2002.
Article
in English
| WPRIM
| ID: wpr-244813
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression and distribution of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in periodontal tissues, and analyze the role of EGF in orthodontic tooth movement.</p><p><b>METHODS</b>According to Kings methods, 40 g mesial force was applied to pull the left maxillary first molar in the rat. Using immunohistochemical method (HI-SABC method) to localize and examine the expression of EGF and EGFR in decalcified alveodental connective tissues at 24 hours and 168 hours of tooth movement.</p><p><b>RESULTS</b>EGF and EGFR were stained at some of periodontal ligament of furcation and radical regions in control group. These expressions of EGF and EGFR increased in periodontal tissues (P < 0.01), with the expressions at 168 hours higher than those at 24 hours (P < 0.01). And levels of EGF and EGFR at tension side were higher than those at pressure side at the same time (P < 0.01).</p><p><b>CONCLUSIONS</b>Epidermal growth factor participated in the tissues remodeling during orthodontic tooth movement and especially played a more important role in orthodontic bone formation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontal Ligament
/
Tooth Movement Techniques
/
Periodontium
/
ErbB Receptors
/
EGF Family of Proteins
/
Metabolism
/
Molar
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Stomatology
Year:
2002
Type:
Article
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