Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate whether or not administration of vitamin B(6) (vitB(6)) has preventive effects on cleft palate formation.</p><p><b>METHODS</b>On the 14, 15 day of gestation, the pregnant rats were treated with administration of vitB(6) (10 mg/kg weight im) before and simultaneously with dexamethason (DEX). Compared the palatal cleft incidence of their fetuses with those whose mother were given DEX only.</p><p><b>RESULTS</b>Treatment with administration of vitB(6) before and simultaneously with DEX, the palatal cleft incidence of subject group fetuses (32.35%) was significantly less than that given DEX only (64.52%). The proportion of the palatal cleft type was also changed significantly.</p><p><b>CONCLUSIONS</b>VitB(6) decrease both the incidence and the severity of cleft palate induced by DEX in rats, which indicates VitB(6) may have preventive effects on cleft palate formation.</p>