Research on expression of telomerase in human odontogenic lesions / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 257-259, 2002.
Article
in English
| WPRIM
| ID: wpr-244824
ABSTRACT
<p><b>OBJECTIVE</b>To study hTERT mRNA expression in ameloblastoma (AB) and odontogenic keratocyst (OKC) and to investigate genesis, development and biological characteristics of AB and OKC.</p><p><b>METHODS</b>hTERT mRNA expression in 54 cases of AB, 16 cases of OKC, 7 cases of oral normal mucosa was detected by in situ hybridization.</p><p><b>RESULTS</b>The positive rates of hTERT mRNA in AB, OKC, and oral normal mucosa were 94.4% (51/54), 87.5% (14/16), 1/7, respectively. There was significant statistical difference (P < 0.001). About clinicalpathology of AB, there was no difference for hTERT expression (P > 0.05) hTERT mRNA was positive in peripheral and stellate reticula cells.</p><p><b>CONCLUSIONS</b>(1) hTERT activity plays an important role in genesis, development of AB. (2) hTERT positive rate is related to cell differentiation and clinical biological behavior.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Ameloblastoma
/
Jaw Neoplasms
/
Odontogenic Cysts
/
Odontogenic Tumors
/
Telomerase
/
DNA-Binding Proteins
/
Genetics
/
Metabolism
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Stomatology
Year:
2002
Type:
Article
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