Differential expression of miR-143 in bone marrow cells between acute leukemia patients and normal people and its significance / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 308-311, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-244933
ABSTRACT
MicroRNA abnormality is closely related to the development of acute leukemia. This study was aimed to investigate the differential expression of miR-143 in bone marrow cells between patients with acute leukemia and normal people. Bone marrow cells from 50 AL patients and 20 normal people were collected respectively and the total RNA was isolated routinely. The quantitative real-time PCR (Q-PCR) method was used to detect the expression levels of miR-143 in these specimens. The results showed that compared with the normal people, the expression of miR-143 in AL patients was significantly decreased (p < 0.05), which significantly increased after complete remission; besides, the expression of miR-143 was negatively correlated with the expression of DNMT3A mRNA, a known target gene of miR-143. It is concluded that the expression of miR-143 in bone marrow cells of AL patients is down-regulated which may be related with the development of acute leukemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone Marrow Cells
/
Leukemia
/
Case-Control Studies
/
Gene Expression Regulation, Leukemic
/
Acute Disease
/
MicroRNAs
/
Genetics
/
Metabolism
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2011
Type:
Article
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