Progress of research on Proto-oncogene c-myc, c-myb in platelet diseases / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 274-278, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-244940
ABSTRACT
The Proto-oncogene c-myc and c-myb has been shown to be crucial in the development of the hematopoietic system. The changes in the expression of c-myc are concerned the cell proliferation and differentiation, the expression products of which play an important regulatory role in cell growth, differentiation or malignant transformation. The c-myb involves in transcription and affects cell proliferation, differentiation, apoptosis. More recently, the researches on proto-oncogene c-myc, c-myb in hematopoietic regulation have gradually increased along with development of molecular biology, molecular immunology and cell biology. Scientists point out that the directive differentiation of erythroid and megakaryocytic progenitors, and platelet abnormalities all relate to the level of their expressions. The most common thrombocytopathy includes thrombocytopenia, thrombocytosis and so on. The etiology and the mechanism of these diseases are unknown. This article reviews the structure, function and the expression of c-myc and c-myb in platelet diseases and their significance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Platelet Disorders
/
Proto-Oncogene Proteins c-myc
/
Proto-Oncogene Proteins c-myb
/
Genetics
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS