MicroRNA and multiple myeloma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 244-248, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-244945
ABSTRACT
MicroRNA (miRNA) represents a new class of endogenous, non-coding small RNA molecules that functions as gene regulator. They can repress the expression of target genes at the post-transcriptional level by base pairing to the 3'-untranslated region of the respective target mRNAs. miRNA plays important roles in the regulation of cell proliferation, metabolism, apoptosis and differentiation. The dysregulation of miRNA expression contributes to tumorigenesis. This review summarizes recent progress of research on the characteristics and function of miRNA, as well as the role of miRNA in multiple myeloma development, abnormal karyotype in chromosomes and drug-resistant.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
MicroRNAs
/
Genetics
/
Multiple Myeloma
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2011
Type:
Article
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