Meroterpenoids and isoberkedienolactone from endophytic fungus Penicillium sp. associated with Dysosma versipellis / 药学学报
Acta Pharmaceutica Sinica
;
(12): 913-920, 2014.
Article
in English
| WPRIM
| ID: wpr-244995
ABSTRACT
Seven meroterpenoids and five small-molecular precursors were isolated from Penicillium sp., an endophytic fungus from Dysosma versipellis. The structures of new compounds, 11beta-acetoxyisoaustinone (1) and isoberkedienolactone (2) were elucidated based on analysis of the spectral data, and the absolute configuration of 2 was established by TDDFT ECD calculation with satisfactory match to its experimental ECD data. Meroterpenoids originated tetraketide and pentaketide precursors, resepectively, were found to be simultaneously produced in specific fungus of Penicillium species. These compounds showed weak cytotoxicity in vitro against HCT-116, HepG2, BGC-823, NCI-H1650, and A2780 cell lines with IC 50 > 10 micromol x L(-1).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penicillium
/
Pharmacology
/
Cell Line
/
Chemistry
/
Berberidaceae
/
Monoterpenes
/
Cell Line, Tumor
/
Lactones
/
Microbiology
Limits:
Humans
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2014
Type:
Article
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