Design, synthesis and biological evaluation of fingolimod analogues containing diphenyl ether moiety / 药学学报
Acta Pharmaceutica Sinica
;
(12): 896-904, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-244997
ABSTRACT
A novel series of fingolimod analogues containing diphenyl ether moiety were designed and synthesized based on the modification of immunosuppressive agent fingolimod used in the treatment of multiple sclerosis. Compounds were evaluated in vivo for lymphopenic activity and heart rate affection. Most compounds showed moderate lymphopenic activity. It is worth noting that compounds 6c, 6d and 14c-14e showed considerable immunosuppressive activities comparable to fingolimod. And compound 14e had no effect on heart rate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Phenyl Ethers
/
Structure-Activity Relationship
/
Chemistry
/
Fingolimod Hydrochloride
/
Heart Rate
/
Immunosuppressive Agents
/
Lymphopenia
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2014
Type:
Article
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