Rosiglitazone improves learning and memory impairment of 3 x Tg mice / 药学学报
Acta Pharmaceutica Sinica
;
(12): 807-812, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-245011
ABSTRACT
This study is to investigate the protective effect of rosiglitazone (RSG) against learning and memory impairment of APP/PS1/tau transgenic mice. AD mice model was replicated by using 6-month APP/PS1/tau transgenic mice. The learning and memory ability of mice was evaluated by Morris water maze and Western blotting assays was applied to measure the phosphorylation and O-glycosylation of Tau and neurofilaments (NFs) protein. The results demonstrated that RSG could reverse the learning and memory deficits of 3 x Tg mice significantly. It was also found that RSG could suppress the hyperphosphorylation of Tau and NFs protein levels and increase the glycosylation expression of Tau and NFs proteins in 3 x Tg mice brain. Together, RSG ameliorates cognitive impairments of 3 x Tg mice via the alleviation of the hyperphosphorylated Tau and NFs proteins burden in the brain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phosphorylation
/
Glycosylation
/
Brain
/
Mice, Transgenic
/
Amyloid beta-Peptides
/
Neurofilament Proteins
/
Tau Proteins
/
Thiazolidinediones
/
Disease Models, Animal
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2014
Type:
Article
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