Synthesis and in vitro cytotoxic activities of sorafenib derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 639-643, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-245034
ABSTRACT
A series of novel sorafenib analogues were designed and synthesized. The cytotoxic activities of these compounds were tested in four tumor cell lines. Some of the compounds showed potent antiproliferative activity against the tested cell lines with IC50 = 4-20 micromol x L(-1). Some compounds demonstrated competitive antiproliferative activities to sorafenib against tested cancer cell lines. Among them, compound 7c demonstrated significant inhibitory activities on ACHN, HCT116 and MDA-MB-231 cell lines with IC50 values of 9.01, 4.97, 6.61 micromol x L(-1), respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phenylurea Compounds
/
Structure-Activity Relationship
/
Molecular Structure
/
Chemistry
/
Niacinamide
/
Inhibitory Concentration 50
/
Cell Line, Tumor
/
Cell Proliferation
/
Antineoplastic Agents
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2014
Type:
Article
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