The basic functions of inosine 5'-monophosphate dehydrogenase and its application in drug discovery / 药学学报
Acta Pharmaceutica Sinica
;
(12): 285-292, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-245087
ABSTRACT
Inosine 5'-monophosphate dehydrogenase (IMPDH) is a key enzyme of de novo GMP biosynthesis. The expression and activity of IMPDH can be affected by diseases and physiological process. It is the drug target for anticancer, antiviral, antimicrobial and immunosuppressive therapeutics. Not only catalytic action but the other biological functions of IMPDH also play an important role in diseases. The basic functions, mechanism of catalysis, classification of inhibitors, biological functions and the latest advances to IMPDH will be illustrated in this review. It is expected to be helpful to the discovery of new inhibitors and biological functions of IMPDH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Polymorphism, Genetic
/
Binding Sites
/
Drug Design
/
Molecular Structure
/
Catalysis
/
Classification
/
Enzyme Inhibitors
/
Drug Discovery
/
Genetics
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2014
Type:
Article
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