Genetic polymorphisms, function and clinical effect of HLA-G / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 350-353, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-245302
ABSTRACT
HLA-G is a non-classical major histocompatibility complex class I molecule that differs from the classical HLA I class molecules by (1) a limited polymorphism, (2) a tissue-restricted distribution and (3) a transcription of spliced messenger RNAs encoding for at least four membrane-bound and two soluble HLA-G isoforms. Extensive studies over the past few years have identified HLA-G as a molecule involved in immune tolerance. In this review, attempts were made to summarize the current state of knowledge of the polymorphisms, expression, function, the effects of HLA-G on immuno-associated disease, evolution of HLA-G and its utility in disease therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Trophoblasts
/
Killer Cells, Natural
/
T-Lymphocytes, Cytotoxic
/
Histocompatibility Antigens Class I
/
Alleles
/
Allergy and Immunology
/
HLA-G Antigens
/
Genetics
/
HLA Antigens
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2002
Type:
Article
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