Analysis on polymorphism in exons 2,3 and 4 of the MICA gene in three different Chinese populations / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To detect genetic polymorphism in the exons 2 to 4 of the MICA gene in Chinese Han population in Shanghai, Dai population in Yunnan province and Uygur population in Xinjiang province respectively.</p><p><b>METHODS</b>DNA samples from 183 random healthy individuals in Han population, 41 in Dai population and 66 in Uygur population were genotyped by using the polymerase chain reaction (PCR) and sequence-specific oligonucleotide probing (SSOP) method.</p><p><b>RESULTS</b>In total, 10, 7 and 9 alleles of MICA were observed in Han, Dai and Uygur population respectively. MICA*008 was the most common allele in the population of both Han and Uygur, whereas MICA*010 was the most popular one in Dai population. Han and Dai had a bit similar distribution pattern (Chi-square=12.809 P=0.046), in contrast with Han to Uygur (Chi-square=58.499 P=0) and Dai to Uygur (Chi-square=49.273 P=0).</p><p><b>CONCLUSION</b>MICA gene displayed different allele distributions in different populations.</p>