Association of HLA-DQB1 alleles and dermatomyositis/ polymyositis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 322-323, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-245309
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate further the nature of HLA-DQB1 alleles association with dermatomyositis/polymyositis (DM/PM).</p><p><b>METHODS</b>HLA-DQB1 typing of 52 patients with DM/PM were investigated by polymerase chain reaction-sequence specific primer method, and the frequencies of HLA-DQB1 alleles were compared.</p><p><b>RESULTS</b>It was found that the patients with DM/PM had significantly increased frequency of HLA-DQB1*0401(RR=3.56, P=1.79 10(-3), Pc<0.05).</p><p><b>CONCLUSION</b>The results suggest that HLA-DQB1*0401 gene contribute to genetic susceptibility to DM/PM.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
HLA-DQ Antigens
/
Dermatomyositis
/
Alleles
/
HLA-DQ beta-Chains
/
Gene Frequency
/
Genetics
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2002
Type:
Article
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