A study of the relationship between MICA gene and systemic lupus erythematosus / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 298-301, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-245314
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between major histocompatibility complex class I chain-related A(MICA) gene and systemic lupus erythematosus (SLE).</p><p><b>METHODS</b>The alleles and frequencies of exons 4 and 5 of MICA gene were determined in 70 cases of SLE and 152 controls of Yunnan Hans by STR genotyping, polymerase chain reaction, single strand conformation polymorphism and bidirection DNA sequencing.</p><p><b>RESULTS</b>Five alleles of exon 5 and 10 alleles of exon 4 were found in this study. The frequency of each allele was determined in patients and controls. There was no significant difference between the two groups in exons 4 and 5 of MICA gene.</p><p><b>CONCLUSION</b>Exons 4 and 5 of MICA were not related to SLE in Yunnan Hans.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA
/
Histocompatibility Antigens Class I
/
China
/
Polymorphism, Single-Stranded Conformational
/
Alleles
/
Gene Frequency
/
Genetics
/
Genotype
/
Lupus Erythematosus, Systemic
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2002
Type:
Article
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