Comparative study of HLA-DQA1 and HLA-DRB1 allele in patients with endometriosis and adenomyosis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 49-51, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-245366
ABSTRACT
<p><b>OBJECTIVE</b>To make a comparative study of HLA-DQA1 and HLA-DRB1 allele frequencies in the cases of endometriosis and adeonmyosis.</p><p><b>METHODS</b>The allelic types of HLA-DQA1 and HLA-DRB1 were detected by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in 51 cases of endometriosis, 45 cases of adenomyosis, and 44 normal individuals as the control.</p><p><b>RESULTS</b>The frequencies of HLA-DQA1*0401(7.8%, 10.0%) were significantly increased in the endometriosis group and the adenomyosis group (Pc=0.03, Pc=0.01), and the frequencies of HLA-DQA1*0301(8.8%, 5.6%) were significantly decreased in these two groups (Pc=0.00, Pc=0.00).There was no significant difference between the frequencies of HLA-DQA1 and HLA-DRB1 of endometriosis and adenomyosis.</p><p><b>CONCLUSION</b>The results indicate that HLA-DQA1*0301 and *0401 alleles are associated with both endometriosis and adenomyosis, and there is perhaps common mechanism involved in both endometriosis and adenomyosis based on HLA-DQA1 and HLA-DRB1 allele frequencies.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
HLA-DQ Antigens
/
HLA-DR Antigens
/
Polymerase Chain Reaction
/
Genetic Predisposition to Disease
/
Asian People
/
Endometriosis
/
HLA-DQ alpha-Chains
/
HLA-DRB1 Chains
/
Gene Frequency
/
Genetics
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2002
Type:
Article
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