Multiplicity analysis on the risk factors of patients with Tourette syndrome to develop the comorbidity of attention-deficit hyperactivity disorder / 中华儿科杂志
Chinese Journal of Pediatrics
;
(12): 342-345, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-245400
ABSTRACT
<p><b>OBJECTIVE</b>To explore risk factors of patients with Tourette syndrome (TS) to develop the comorbidity attention-deficit hyperactivity disorder (ADHD) (TS + ADHD), so as to provide evidence for its prevention and intervention.</p><p><b>METHODS</b>A total of 150 patients with TS were divided into two groups (TS group; TS + ADHD group) according to DSM-IV with 75 patients in each group. All the enrolled patients were investigated using self-designed questionnaire and Family Environment Scale-Chinese Edition (FES-CV). Forty-six factors were used as variables and were quantified. Data were analyzed by SPSS10.0 and the odds ratios of different factors to TS + ADHD were calculated by using univariate and multivariate analysis.</p><p><b>RESULTS</b>(1) Families of children with TS + ADHD had lower score in cohesion, expression, intellectual-cultural orientation, active-recreational orientation, moral religious emphasis and organization, but had higher conflict score in FES-CV than the control group. (2) Single-factor analysis indicated that 8 factors were associated with TS + ADHD including ADHD family history positive (OR = 24.318), low family education (OR = 18.617), longer delay of treatment (OR = 10.796), maternal smoking (OR = 9.094), family conflict (OR = 5.781), hypoxia at birth (OR = 2.562), lower culture level of parents (OR = 1.941) and poor expressiveness (OR = 0.967). (3) Five factors including ADHD family history positive (OR = 13.805), family conflict (OR = 8.459), low family education (OR = 5.477), lower culture level of parents (OR = 2.164) and maternal smoking (OR = 2.075) were selected for the multivariate regression analysis.</p><p><b>CONCLUSION</b>The key risk factors of co-occurrence of TS with ADHD were positive ADHD family history, family conflict, low family education, lower culture level of parents and maternal smoking.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Attention Deficit Disorder with Hyperactivity
/
Tourette Syndrome
/
Case-Control Studies
/
Comorbidity
/
Epidemiology
/
Risk Factors
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pediatrics
Year:
2010
Type:
Article
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