Gene expression difference analysis between abdominal aorta aneurysm and normal abdominal artery / 中华外科杂志
Chinese Journal of Surgery
;
(12): 691-693, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-245516
ABSTRACT
<p><b>OBJECTIVE</b>To identify gene expression differences between abdominal aorta aneurysm (AAA) and normal abdominal artery.</p><p><b>METHODS</b>Five AAA specimens and five normal abdominal artery specimens were collected. Total RNA was extracted and purified from the samples independently. Then isolated RNA was labeled and hybridized onto the Affymetrix Genechip.</p><p><b>RESULTS</b>One thousand nine hundreds and sixty-two differently expressed genes were identified in AAA compared with normal abdominal artery, of which 554 genes were up-regulated and 1408 genes were down-regulated. Functional analysis revealed that genes involved in immune response, inflammatory response and chemokines were significantly up-regulated in AAA.</p><p><b>CONCLUSION</b>The differently expressed genes may be useful in providing new insights and foster a better understanding of the mechanism of AAA.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta, Abdominal
/
Aortic Aneurysm, Abdominal
/
Oligonucleotide Array Sequence Analysis
/
Gene Expression Profiling
/
Genetics
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2008
Type:
Article
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