Experimental study on relationship between TCM syndrome type and gastric mucosa cell proliferation in rat model of chronic atrophic gastritis / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 1004-1006, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-245582
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between TCM syndrome type and gastric mucosa cell proliferation related controlling gene protein in chronic atrophic gastritis (CAG).</p><p><b>METHODS</b>Expressions of cell proliferation related controlling gene protein, including proliferative cell nuclear antigen (PCNA), epidermal growth factor receptor (EGFR) and c-myc, from gastric mucosa of CAG model rats with different syndrome types were measured by immunohistochemistry and the changes of them before and after TCM intervention were also analyzed by image analysis.</p><p><b>RESULTS</b>Protein expressions of PCNA, EGFR and c-myc in gastric mucosa of CAG model rats with different syndrome types (Pi-deficiency type, Gan-stagnation type and dampness-heat type) were different to some extent, and all of them reduced significantly after TCM intervention in the model rats of all syndrome types.</p><p><b>CONCLUSION</b>Expressions of cell proliferation related controlling gene protein in gastric mucosa of CAG model rats of different syndrome types were different to some extent, which provides a certain experimental evidence for revealing the essence of TCM syndrome type of CAG and judging the prognosis of various types.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Syndrome
/
Drugs, Chinese Herbal
/
Immunohistochemistry
/
Random Allocation
/
Proto-Oncogene Proteins c-myc
/
Rats, Wistar
/
Proliferating Cell Nuclear Antigen
/
Therapeutic Uses
/
Diagnosis
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2007
Type:
Article
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