Exploration on relationship between TCM syndrome type and expression of human leucocyte antigen locus-DRB1 in patients with chronic hepatitis B / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 898-900, 2007.
Article
in Zh
| WPRIM
| ID: wpr-245613
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between TCM syndrome type and expression of human leucocyte antigen-DRB1 (HLA-DRB1) in patients with chronic hepatitis B.</p><p><b>METHODS</b>Using PCR method to amplify the related segments of DNA extracted from peripheral leucocytes by the routine methods, and gene array analysis was performed to detect the expression of HLA-DRB1.</p><p><b>RESULTS</b>HLA-DRB1 * 13 was expressed in healthy person in the control group, but was not expressed in chronic hepatitis B patients, showing significant difference between the two groups. In the patients with five different syndrome types, i.e. the dampness blocking middle-jiao type (A), the Gan-stagnancy with Pi-deficiency type (B), the blood stasis blocking collaterals type (C), the Gan-Shen yin-deficiency type (D) and the Pi-Shen yang-deficiency type (E), the former three belonged to the excessive syndrome and the latter two were deficient syndrome. Most of the CHB patients were differentiated as excessive syndrome.</p><p><b>CONCLUSION</b>Difference of HLA-DR expression exists between chronic hepatitis B patients and healthy persons, the action of the difference is remained for further confirmation. HLA-DR expression in patients with different syndrome types, excessive or deficient, might be different, too.</p>
Full text:
1
Index:
WPRIM
Main subject:
Syndrome
/
HLA-DR Antigens
/
Gene Expression
/
Hepatitis B, Chronic
/
Diagnosis
/
Diagnosis, Differential
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Alleles
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Allergy and Immunology
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HLA-DRB1 Chains
/
Gene Frequency
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
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Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2007
Type:
Article