Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 819-821, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-245634
ABSTRACT
<p><b>OBJECTIVE</b>To study the influence of repeated seizures and anti-epileptic drug on phosphorylated cAMP response element binding protein (pCREB) in rat model of cognitive impairment, and the effect of Caoguo Zhimu Decoction (CZD) on it.</p><p><b>METHODS</b>On the basis of epileptic model induced by pentylenetetrazol (PTZ), cognitive impairment model was induced by kindling epilepsy with PTZ everyday, which were then di-vided into the model-1 group, the CZD-1 group, the nimodipine-1 group, and those by injecting large dosage phenytoin sodium were divided into the model-2 group, the CZD-2 group and the nimodipine-2 group. Changes of pCREB protein in rat's hippocampus were detected using immunohistochemistry and Western blotting assay.</p><p><b>RESULTS</b>The expression of pCREB was higher in the CZD-1 and nimodipine-1 group than in the model group, while it was significantly different in the CZD-2 and nimodipine-2 groups than in the model-2 group.</p><p><b>CONCLUSION</b>CZD could relieve the cognitive dysfunction in the epileptic model rats induced by everyday PTZ kindling or by dilantin through increasing the pCREB expression.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pentylenetetrazole
/
Phenytoin
/
Phosphorylation
/
Drugs, Chinese Herbal
/
Random Allocation
/
Rats, Sprague-Dawley
/
Cyclic AMP Response Element-Binding Protein
/
Cognition Disorders
/
Therapeutic Uses
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2007
Type:
Article
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