Optimization of formulation matrix proportion and preparation technology of realgar floating tablets for gastric retention by uniform design and correlation analysis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 391-393, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-245970
ABSTRACT
<p><b>OBJECTIVE</b>To optimize the different components proportions of the Realgar floating tablets for gastric retention by uniform design and correlation analysis.</p><p><b>METHOD</b>With the different dosage of hydroxypropyl methyl cellulose (HPMC) as the tablets frame matrix, uniform design and correlation analysis were used to optimize the best component proportions of formula, and to measure the dissolution of the tablets in vitro.</p><p><b>RESULT</b>Dissolution of the tablets in vitro was conformed to the expectation of experiment. The drug-release mechanism was by diffusion and corrosion at the same time.</p><p><b>CONCLUSION</b>The Realgar floating tablets for gastric retention achieved the goal of design, which demand sustained release and safety.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arsenicals
/
Solubility
/
Stomach
/
Sulfides
/
Tablets
/
Materia Medica
/
Pharmacokinetics
/
Chemistry
/
Administration, Oral
/
Povidone
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article
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