Norisoprenoids from red alga Gymnogongrus flabelliformis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2046-2048, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-246024
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents of the red alga Gymnogongrus flabelliformis Harv.</p><p><b>METHOD</b>Compounds were isolated by normal phase silica gel and Sephadex LH - 20 gel column chromatography and reverse phase HPLC. Their structures were elucidated by spectroscopic methods including MS, 1H-NMR, 13C-NMR. Cytotoxicity of the compounds was screened by using standard MIT method.</p><p><b>RESULT</b>Five compounds were isolated from G. flabelliforrmis, their structures were identified as(3S, 6R, 7E)-( + )-3-hydroxyl-4, 7-mega-stigmadien-9-one (1), (3S, 5R, 6S, 7E)-(-)-3-hydroxy-5, 6-epoxy-7-megastigmene-9-one (2), (3S, 5S, 6R, 7E)-(+)3-hydroxy-5, 6-epoxy-7-megastigmene-9-one (3), dehydrovomifoliol (4), (3R)-(-)4-[(2R, 4S)-4-acetoxy-2-hydroxy-2, 6, 6-trimethylcyclohexylidene] -3-buten-2-one (5).</p><p><b>CONCLUSION</b>All of the compounds were obtained from this species for the first time and compound 1 was a new natural product. These compounds were inactive (IC50 > 10 microg x mL(-1)) in the MTT assay against several human cancer cell lines.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Magnetic Resonance Spectroscopy
/
Cell Survival
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Inhibitory Concentration 50
/
Cyclohexanones
/
Cell Line, Tumor
/
Norisoprenoids
/
Butanols
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2006
Type:
Article
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