Study on effect of pH on rectum permeability of active ingredients in Reduning suppositories in vitro / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1493-1496, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-246071
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of different pH on rectum permeability of chlorogenic acid and geniposide.</p><p><b>METHOD</b>Four kinds of Reduning suppositories of different pH were separated and put into the rectum to study the suppositories in vitro and the content of chlorogenic acid and geniposide samples was determined by HPLC to calculate the permeation in 24 hours.</p><p><b>RESULT</b>With increase of pH within 2.5-7.4, the steady state flux of chlorogenic acid was increased, but the steady state flux of geniposidesamples was steady.</p><p><b>CONCLUSION</b>Adjusted the pH can increase the rectum permeability of active ingredients in Reduning auppositories.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Rectum
/
Suppositories
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Chlorogenic Acid
/
Rats, Sprague-Dawley
/
Iridoids
/
Hydrogen-Ion Concentration
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article
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