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Relationship between mannose-binding protein gene polymorphisms and disease progression and HBV DNA in patients with chronic HBV infection / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 90-92, 2012.
Article in Chinese | WPRIM | ID: wpr-246172
ABSTRACT
<p><b>OBJECTIVE</b>To determine the influences of Mannose binding protein (MBP) gene polymorphisms on HBV DNA loads and on the progression of liver disease in patients with chronic HBV infection.</p><p><b>METHOD</b>The Codons on 54 MBP gene polymorphisms and HBV DNA loads in a cohort of 395 patients with chronic HBV infection, including 244 with chronic hepatitis B (CHB), 151 with liver cirrhosis (LC) and 88 normal controls were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and fluorescent quantitative PCR (FQ-PCR).</p><p><b>RESULT</b>The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC in CHB group showed no significant differences comparing to the normal control group (P > 0.05). The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC on CHB group (severe), compensation phase of LC group and decompensation phase of LC group were higher than those in the normal control group (P < 0.05), the genetic polymorphism of decompensation of LC was 36.5%, highest of all. The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC of patients with chronic HBV infection were not changed with the differences of HBV-DNA loads.</p><p><b>CONCLUSION</b>The codes on 54 MBP gene polymorphisms is not closely related to HBV DNA loads, but was associated with the progression of hepatitis B infection.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / DNA, Viral / Cohort Studies / Disease Progression / Hepatitis B, Chronic / Mannose-Binding Lectin / Gene Frequency / Genetics / Genotype Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / DNA, Viral / Cohort Studies / Disease Progression / Hepatitis B, Chronic / Mannose-Binding Lectin / Gene Frequency / Genetics / Genotype Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2012 Type: Article