Clinical study of tissue expression and serum contents of VEGF-C in cervical diseases of Uighur women / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 60-62, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-246180
ABSTRACT
<p><b>OBJECTIVE</b>To detect the VEGF-C expression in the serum and tissue of cervical diseases. To explore correlation of tissue and serum expression and the clinical significance of VEGF-C in the cervical intraepithelial neoplasia and cervical squamous-celled carcinoma of Uighur momen in Xinjiang.</p><p><b>METHOD</b>(1) The VEGF- C expressions in tissue were tested by immunohistochemisty from the 22 chronic cervicitis, 24 CIN,and 43 squamous-celled carcinoma patients, (2) The VEGF-C contents in the serum were tested by enzyme-linked immunosorbent assay (ELISA) from the 15 chronic cervicitis, 23 CIN, and 40 squamous-celled carcinoma patients.</p><p><b>RESULT</b>(1) The expression of VEGF-C in the tissue of cervicitis, CIN and cervical carcinoma were separately 9.1%, 87.50%, 100%, the differences had significance (P < 0.05). (2) The VEGF-C serum contents were gradually increased from cervicitis to CIN and cervical carcinoma, the differences had significance (P < 0.05). (3) The compartment of results of VEGF-C in serum and tissue showed that, there were correlation between to of them, the more tissue expressions, the more serum expressions will be (r = 0.27, F = 5.327, P < 0.05).</p><p><b>CONCLUSION</b>VEGF-C has played an facilitation rule in the transition process of CIN to cervical squamous cell carcinoma of the Uygure women in Xinjiang, there are correlation of VEGF-C expression between tissue and serum.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Blood
/
Enzyme-Linked Immunosorbent Assay
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Uterine Cervical Dysplasia
/
Uterine Cervical Neoplasms
/
China
/
Vascular Endothelial Growth Factor C
/
Ethnology
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2012
Type:
Article
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