Investigation of the relationship between apolipoprotein gene polymorphism and hepatitis B virus infection in China / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 28-30, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-246191
ABSTRACT
<p><b>OBJECTIVE</b>To explore the gene polymorphisms of ApoAI-75 Msp1, ApoB Msp1, ApoCIII Sst1, LRP5, and ApoE genotypes in two pairs of semi different modes of hepatitis B for HBV markers.</p><p><b>METHODS</b>The patients are divided into 9 groups. There were a total of 720 cases, 80 patients in each group, The patients was carried out by SnaPshot method (single-base multilocus micro-sequencing), and different genotypes of each locus were conducted by the method of sequencing in order to support the final evidence of the accuracy of test results.</p><p><b>RESULTS</b>There was association between gene polymorphisms of ApoAI-75Msp1 and ApoE and different modes of two pairs of semi-hepatitis B (P < 0.05), while there wasn't any association between gene polymorphisms of ApoB-Msp1, ApoCIII-Sst1, LRP5 and different modes of two pairs of semi-hepatitis B (P > 0.05).</p><p><b>CONCLUSION</b>The gene polymorphism of ApoAI-75Msp1 and ApoE was associated with the different modes of HBV markers.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins
/
Apolipoproteins B
/
Polymorphism, Genetic
/
China
/
Apolipoprotein A-I
/
Apolipoprotein C-III
/
Genetics
/
Genotype
/
Hepatitis B
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2012
Type:
Article
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