Epidemiological study and clinical analysis of 931 children with hand foot and mouth disease in Yantai / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To discuss the epidemiological and clinical characteristics of the hospitalized children with hand foot and mouth disease (HFMD) in Yantai area.</p><p><b>METHODS</b>Epidemiological and clinical data of HFMD children from 2009 to 2010 were summarized and analyzed retrospectively.</p><p><b>RESULTS</b>Most of the infected (94.6%) were under 5 years old and the ratio between male and female was 1.5 1. Oral mucosal pox or ulcer as well as hand and foot rashes were observed in all 931 patients. Fever and neurological disorders occurred in 840 (90.2%) and 121 (13.0%) patients respectively. The incidence was positively correlated with air temperature (r = 0.887, P < 0.001), with a peak in April to September (88.9%). The ratio of children from countryside, total duration of fever, serum concentration of c-reacting protein (CRP) and fasting blood glucose (FBG) were significantly higher in severe cases than in those mild ones. Multivariate analysis showed longer mean duration of fever( Odds ratio [OR], 1.491; 95% confidence interval [ CI] 1.170-1.901; P = 0.001) and hyperglycemia (OR, 1.124; 95% CI 1.016-1.245; P = 0.024) were independent risk factors of severity.</p><p><b>CONCLUSION</b>Children younger than 5 years old are susceptible to HFMD and most cases occur in April to September. The monthly incidence is positively correlated with temperature of that month. Longer duration of fever and hyperglycemia are independent risk factors for severity. Most cases could have a favorable prognosis after timely diagnosis and proper intervention.</p>