The study of combining high-risk human papillomavirus types checking and cytologic test in the screening of cervical lesions / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 298-300, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-246259
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between thinprep cytologic test and the types of human papilloma virus (HPV) infection in cervical precancerous lesion screening.</p><p><b>METHODS</b>To perform high-risk HPV types test in 1375 samples. Choose 256 positive samples to take thinprep cytologic test (TCT) and directed biopsies under colposcopy. Adopting two-channels real time PCR to genotype and quantify eight high risk HPV DNA (high risk types HPV 16, 18, 45, 31; intermediate risk types HPV 33, 52, 58, 67).</p><p><b>RESULTS</b>There are 256 positive samples in High risk HPV DNA test (18.62%). WNL rate for TCT is 16.41% (42/256), ASCUS and above rate for TCT is 83.59% (214/256). There is no statistically significant difference in the viral loads of HPV infection rate between the TCT negative patients and positive patients (P > 0.5). Positive correspondence rate for TCT and biopsy are 92.86% (39/42), 81.36% (48/59), 85.19% (23/27) and 9/10.</p><p><b>CONCLUSION</b>High-risk HPV types checking combined with TCT and biopsy can raise positive rate significantly. It should be used as a reliable method for early diagnosis in cervical cancer and CIN screening.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Virology
/
Uterine Cervical Neoplasms
/
Classification
/
Cytodiagnosis
/
Papillomavirus Infections
/
Diagnosis
/
Alphapapillomavirus
/
Early Detection of Cancer
/
Genetics
Type of study:
Diagnostic study
/
Etiology study
/
Screening study
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2011
Type:
Article
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