Surveillance finding on rotavirus in Changchun children's hospital during July 1998-June 2001 / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 1010-1012, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-246415
ABSTRACT
<p><b>OBJECTIVE</b>To establish baseline patterns of rotavirus diarrhea and to describe its epidemiologic features in Changchun city, prior to rotavirus vaccine immunization.</p><p><b>METHODS</b>Hospital-based surveillance was conducted among children under 5 years old with acute diarrhea in Changchun Children's Hospital. Fecal samples were determined to identify rotavirus by PAGE and/or ELISA. G serotypes of rotavirus were identified by ELISA and/or nested RT-PCR. P genotyping were carried out by RT-PCR. All data were computerized and analysed by "Generic Manual on Rotavirus Surveillance" set by CDC in the USA.</p><p><b>RESULTS</b>In total, 2 343 diarrhea cases were screened and 1 211 fecal samples were collected. Rotavirus was detected in 31.0% among outpatients and 52.9% in inpatients. During the peak of the season (November through March), 58.6% of diarrhea was caused by rotavirus among inpatients. 95.0% of rotavirus diarrhea cases occurred among children aged < 2 years. The predominant strain was serotype G1 (82.4%), followed by G2 (5.0%), G3 (3.3%), G4 (0.9%). P genotyping showed that P[8] and P[4] were the most common ones. Nine different P-G combinations were identified, four strains (P[8]G1, P[4]G2, P[8]G3, and P[8]G4) commonly seen worldwide accounted for 75.6% of the total. Taken together with uncommon strains, including the novel types P[4]G4 and P[8]G2, it highlights the extraordinary diversity of rotaviruses circulating in China.</p><p><b>CONCLUSION</b>Rotavirus is the major cause of severe child diarrhea in Changchun. Developing a rotavirus vaccine for prevention of severe disease and reduction of treatment costs seemed to be necessary.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rotavirus Infections
/
Virology
/
Enzyme-Linked Immunosorbent Assay
/
Serotyping
/
China
/
Epidemiology
/
Classification
/
Rotavirus
/
Sentinel Surveillance
/
Reverse Transcriptase Polymerase Chain Reaction
Type of study:
Practice guideline
/
Screening study
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS