Study on the correlation between the different papillomavirus type and telomerase in cervical cancer / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To define a correlation between different human papillomavirus (HPV) types and telomerase activity in cervical cancer.</p><p><b>METHODS</b>Telomerase activity was detected by TRAP-PCR, and different HPV type was determined by PCR in 83 cervical cancer, 47 cervical intraepithelial neoplasia (CIN) and 10 normal cervix cases.</p><p><b>RESULTS</b>With regard to positive rates of telomerase and HPV 16/18 the results were cervical cancer > CIN > normal cervix, CIN III > CIN I, II; with regard to HPV 6/11 positive rate the results showed CIN I, II > CIN III. Positive rates of telomerase cervical cancer and HPV were bearing on grading and staging, but they did not correlate with histologic subtypes. Positive rate of HPV 6/11 had nothing to do with grading, staging and histologic patterns. On expression strength of telomerase and HPV 16/18 the results showed cervical cancer > CIN, CIN III > CIN I, II. Regard to HPV 6/11'expression strength the results showed CIN I, II > CIN III, CIN > cervical carcinoma.</p><p><b>CONCLUSION</b>HPV 16/18 infection seemed to have played an important role in carcinogenesis of cervical lesions by activation of telomerase.</p>