Genetic alterations in MAPK and PI3K/Akt signaling pathways and the generation, progression, diagnosis and therapy of thyroid cancer / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1221-1225, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-246476
ABSTRACT
The mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and phoshoinositide-3-kinase/protein kinase B (PI3K/Akt) signaling pathways play a major role in regulating cell growth, proliferation and apoptosis, via transmission of cell signals to cell nucleus. The genes, coding the MAPK/ERK and PI3K/Akt signaling cascade proteins, are significantly mutated in thyroid cancer. Genetic alternations contribute to aberrant activations and interaction of MAPK/ERK and PI3K/Akt signaling pathways in consequence of malignant follicular cell transformation and progression. This review focuses mainly on the role of genetic alterations in coding MAPK/ERK and PI3K/Akt signaling pathway proteins in generation, progression and diagnosis of thyroid cancer. Moreover, it additionally points out a therapeutic potential in restoring iodine avidity of thyroid cancer cells for radionuclide targeted treatment, by synergistically inhibiting activity of signaling pathways.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Therapeutics
/
Thyroid Neoplasms
/
Signal Transduction
/
Phosphatidylinositol 3-Kinases
/
Mitogen-Activated Protein Kinases
/
MAP Kinase Signaling System
/
Extracellular Signal-Regulated MAP Kinases
/
Proto-Oncogene Proteins c-akt
/
Genetics
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2012
Type:
Article
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