Association between interferon regulatory factor 6 gene polymorphism and non-syndromic oral clefting / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 352-360, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-246586
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between interferon regulatory factor 6 (IRF6) gene polymorphism and non-syndromic oral clefting (NSOC).</p><p><b>METHODS</b>Experimental group consisted of 186 Ningxia NSOC patients, their parents (183 fathers and 174 mothers), 172 core families (patient+parents), and control group consisted of 200 normal children. DNA was extracted and PCR-restriction fragment length polymorphism (PCR-RFLP) was used to identify the genotypes of the samples, case-control analyses and transmission-disequilibrium test (TDT) were carried out.</p><p><b>RESULTS</b>Compared with control group, there were significant differences in both rs642961's and rs4844880's AA genotype and A allele among NSOC patients (P < 0.05), but no difference in cleft palate (P = 0.15, P = 0.967, respectively). In TDT analysis, the A allele of rs642961 had a strong over-transmission in NSOC (P < 0.05), so did the rs4844880'A allele (P < 0.05), but neither of them had significant difference in cleft palate (P = 0.91, P = 0.95, respectively).</p><p><b>CONCLUSION</b>IRF6 gene polymorphism is associated with NSOC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Case-Control Studies
/
Cleft Palate
/
Interferon Regulatory Factors
/
Genetics
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2010
Type:
Article
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