Reseach Progress of Ki-67 in Acute Myeloid Leukemia-Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1264-1268, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-246778
ABSTRACT
Ki-67 antigen expression is closely associated with the cell cycle. Its expression is in almost the entire mitosis in cell cycle. Detection of Ki-67 antigen can reflect the cell proliferation activity in hematological malignancies. Detection of Ki-67 has been widely applied in staging, therapy effect monitoring and prognosis judgment in lymphoma. There has been a lot of studies investigating the expression of Ki-67 in acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL), and investigating the relevance between Ki-67 expression and therapy effect and prognosis. However, there are a few studies about Ki-67 in acute myeloid leukemia (AML), and the results of studies are no consistant. In this review, the architecture, intracellular localization, expression regulation, physiological functions of Ki-67 and the application of Ki-67 in AML are summarized so as to understanding whether Ki-67 can play roles in diagnosis and prognostic evaluation of AML.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Leukemia, Myeloid, Acute
/
Cell Cycle
/
Cell Division
/
Ki-67 Antigen
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2016
Type:
Article
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