Research Progress on CALR Mutation in the Myeloproliterative Neoplasm -Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1252-1255, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-246781
ABSTRACT
There is no gold diagnostic standard for BCR-ABL fusion gene negative chronic myeloproliterative neoplasm(cMPN). The following detection methods such as comprehensive bone marrow cell morphology, bone marrow pathology, genetic mutation, flow cytometry and immunohistochemical are needed to diagnose the BCR-ABL fusion gene positive cMPN. The JAK2 mutation can be used as a specific diagnostic criteria for polycythemia vera (PV), but there is no specific and sensitive indication for the JAK2 mutation-negative MPN. CALR mutation would be an indication in a certain extent. In this review, the CALR mutation detection, detection mean and its correlation with disease diagnosis and prognosis etc were summarized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Bone Marrow
/
Bone Marrow Cells
/
Calreticulin
/
Mutation
/
Myeloproliferative Disorders
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2016
Type:
Article
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