Relaxin inhibit cardiac fibrosis induced by phorbol 12-myristate 13-acetate / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 138-141, 2014.
Article
in English
| WPRIM
| ID: wpr-247071
ABSTRACT
Relaxin is known to inhibit cardiac fibrosis. However, it is unclear whether relaxin could regulate the effects of Phorbol 12-myristate 13-acetate (PMA, PKC activator) on cardiac fibrosis. So the influence of relaxin on the cell proliferation and collagen expression induced by PMA in cultured cardiac fibroblasts was studied. It showed that PMA significantly increased cardiac fibroblasts proliferation, Type I pro-collagen protein expression, Type I pro-collagen mRNA expression, and rhRLX absolutely significantly decreased PMA induced effects on cardiac fibroblasts proliferation and Type I pro-collagen expressions, indicating that relaxin could inhibit cardiac fibrosis induced by PMA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Relaxin
/
Fibrosis
/
Tetradecanoylphorbol Acetate
/
Cells, Cultured
/
Rats, Sprague-Dawley
/
Therapeutic Uses
/
Fibroblasts
/
Heart Diseases
/
Animals, Newborn
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2014
Type:
Article
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