Serum folate, MTHFR C677T polymorphism and esophageal squamous cell carcinoma risk / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 1008-1012, 2013.
Article
in English
| WPRIM
| ID: wpr-247095
ABSTRACT
This study examined associations between MTHFR C677T polymorphism and serum folate concentrations with the risk of esophageal precancerous lesions (EPL) and esophageal squamous cell carcinoma (ESCC). The highest quartile of serum folate concentration significantly decreased the risk of ESCC compared with the lowest quartile (OR=0.11; 95% Cl, 0.04-0.33; P<0.05). MTHFR 677 C>T polymorphism was associated with the risk of ESCC by using chi-square tests (P<0.05). For the CT genotype, the risk of ESCC significantly increased in study participants with low serm folate concentrations (≤26.92 μg/L) compared with participants with high serum folate concentrations (>26.92 μg/L) by using multinomial logistic regression models. The MTHFR genotype may further modify associations between serum folate concentrations and the risk of ESCC, but it was not significantly associated with the risk of EPL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Blood
/
Esophageal Neoplasms
/
Carcinoma, Squamous Cell
/
Chi-Square Distribution
/
Genetic Predisposition to Disease
/
Methylenetetrahydrofolate Reductase (NADPH2)
/
Folic Acid
/
Genetics
Type of study:
Etiology study
Limits:
Humans
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2013
Type:
Article
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