N-hexane alters the maturation of oocytes and induces apoptosis in mice / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 735-741, 2013.
Article
in English
| WPRIM
| ID: wpr-247140
ABSTRACT
<p><b>OBJECTIVE</b>This study was aimed to determine the effects of n-hexane on the maturation of mouse oocytes.</p><p><b>METHODS</b>Cell culture was used to observe the maturation of mouse oocytes and CLSM was employed to determine their apoptosis.</p><p><b>RESULTS</b>Germinal vesicle breakdown (GVBD) and extrusion of the first polar body in mouse oocytes were significantly inhibited by n-hexane. After fertilization, the number of eggs in the mouse was significantly reduced by n-hexane. Mitochondrial membrane potentials (ΔΨm) were altered in mouse oocytes that were leading to apoptosis of the oocytes.</p><p><b>CONCLUSION</b>N-hexane might have affected the maturation of oocytes, causing alteration of ΔΨm and leading to apoptosis which maybe one of the most important mechanisms.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oocytes
/
Apoptosis
/
Environmental Pollutants
/
Toxicity
/
Membrane Potential, Mitochondrial
/
Fertilization
/
Hexanes
/
Mice, Inbred ICR
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2013
Type:
Article
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