Effects of sea cucumber cerebroside and its long-chain base on lipid and glucose metabolism in obese mice / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 60-64, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-247183
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of sea cucumber cerebroside(SCC) and its long-chain base(LCB) on lipid and glucose metabolism in obese mice.</p><p><b>METHODS</b>The mouse obese model was established by feeding high fat diet. The mice were randomly assigned to 4 groups control group, model group, SCC group and LCB group. After 4 weeks, the glucose tolerance test was undertaken. After 5 weeks, the body fat content, organic indexes, serum lipid level, glycemic index and liver lipid level were determined.</p><p><b>RESULTS</b>Compared with the model group, the glucose tolerance in the SCC group and LCB group was ameliorated significantly (P<0.01, P<0.05); glycemic index (P<0.01, P<0.01), the weight of adipose tissue (P<0.05, P<0.01) and the hepatic TG were reduced significantly (P<0.05, P<0.05).</p><p><b>CONCLUSION</b>Sea cucumber cerebroside and its long-chain base can improve the glucose and lipid metabolism in obese mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Sea Cucumbers
/
Blood
/
Blood Glucose
/
Cerebrosides
/
Chemistry
/
Drug Therapy
/
Lipid Metabolism
/
Lipids
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2012
Type:
Article
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