Screening and identifying hepatotoxic components in Aucklandiae Radix with GC-MS / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To screen the potential hepatotoxic components in Chinese herb medicine Aucklandiae Radix.</p><p><b>METHODS</b>The potential hepatotoxic components were screened using HepG2 cells labeled with fluorescein diacetate from 25 fractions of Aucklandiae Radix, in which the hepatotoxic compounds were further identified with GC-MS.</p><p><b>RESULTS</b>Ten potential hepatotoxic fractions were screened. The identification results by GC-MS indicated that the main compounds in C09 were dehydrocostuslactone, santamarine (or magnolialide) and reynosin, and in C11 were α-costol and elemol.</p><p><b>CONCLUSION</b>Dehydrocostuslactone, santamarine (or magnolialide), reynosin, α-costol and elemol are potential hepatotoxic compounds in Aucklandiae Radix.</p>