Effect of venlafaxine on cognitive function and hippocampal brain-derived neurotrophic factor expression in rats with post-stroke depression / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 527-534, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-247219
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of venlafaxine on the cognitive impairment of learning and memory in rats with post-stroke depression (PSD) and to investigate its relationship with the expression of brain-derived neurotrophic factor (BDNF) in hippocampus.</p><p><b>METHODS</b>Fifty male adult SD rats were randomly divided into control group, model group and three treatment groups (5,10, 20 mg*kg(-1) venlafaxine) with ten in each group. After the procedure of selective cerebral right middle artery embolism, a paradigm of continuous 3-week chronic unpredictable mild stress (CUMS) was used to induce PSD. Along with the course of CUMS the peritoneal injection at different dose levels of venlafaxine were performed once a day in PSD rats in a fixed time interval. Morris water maze test was applied to assess the spatial learning and memory function and immunohistochemical staining was used to detect the change of BDNF expression.</p><p><b>RESULTS</b>The learning function decreased significantly in PSD rats compared with the control (P<0.05), as well as in spatial exploring time (14.2 s ± 4.8 s Compared with 45.9 s ± 4.5 s) and frequency of spanning platform (1.3 ± 0.3 Compared with 8.3 ± 1.1). Moreover,very fewer BDNF positive cells were found in CA3 area of hippocampus in model group in comparison with the control group (9.8 ± 3.2 Compared with 18.5 ± 4.7). After different dosage of venlafaxine treatment, the BDNF expression and cognition increased markedly.</p><p><b>CONCLUSION</b>Venlafaxine can improve PSD-induced learning and memory dysfunction, possibly through the enhancement of the BDNF level in the CA3 area of hippocampus.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rats, Sprague-Dawley
/
Maze Learning
/
Brain-Derived Neurotrophic Factor
/
Stroke
/
Cyclohexanols
/
Therapeutic Uses
/
Depression
/
Disease Models, Animal
/
Drug Therapy
/
Venlafaxine Hydrochloride
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2011
Type:
Article
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