Two Cases of Nephrolithiasis Following Administration of Cyclosporine / 대한신장학회지
Korean Journal of Nephrology
;
: 600-605, 2008.
Article
in Korean
| WPRIM
| ID: wpr-24722
ABSTRACT
Cyclosporine is one of the most useful immunosuppressants for many diseases including nephrotic syndrome, glomerulonephritis, organ transplantation, and other autoimmune diseases. However, cyclosporine is known to cause renal tubular acidosis (RTA) due to a decrease in urinary ammonium excretion. Cyclosporine also can lead to significant hypocitraturia due to a higher proximal tubular reabsorption of citrate and increase the risk for nephrolithiasis. Citrate excretion is essential for the prevention of urinary supersaturation and hypocitraturia is a major risk factor for nephrocalcinosis and nephrolithiasis. Now we report two cases of nephrolithiasis treated with cyclosporine. The first patient is a renal transplantation recipient and the second patient has membranous glomerulonephritis. Therefore, these two cases lead us to conclude that patients treated with cyclosporine have to be regularly followed up for nephrolithiasis caused by cyclosporine-induced tubular dysfunction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoimmune Diseases
/
Acidosis, Renal Tubular
/
Glomerulonephritis, Membranous
/
Risk Factors
/
Organ Transplantation
/
Kidney Transplantation
/
Cyclosporine
/
Citric Acid
/
Transplants
/
Nephrolithiasis
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2008
Type:
Article
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