Screening for the microdeletions of azoospermia factor on the Y chromosome in male infertile patients from Guangzhou / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 564-566, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-247268
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between microdeletion of azoospermia factor (AZF) and male infertility.</p><p><b>METHODS</b>Multiplex PCR was used to detect Y chromosome microdeletion in AZFa, AZFb and AZFc in 103 cases of idiopathic azoospermia, 72 cases of severe idiopathic oligozoospermia, and 60 healthy male controls.</p><p><b>RESULTS</b>No microdeletion was found in 60 controls. Y chromosome microdeletion was found in 19 of 175 azoospermia patients, the total prevalence rate of microdeletion was 10.9%. There were 15 cases (11 for azoospermia, 4 for severe oligozoospermia) in AZFc (8.6%), 3 cases (1 for azoospermia, 2 for severe oligozoospermia) in AZFb+c (1.7%), 1 case (azoospermia) in AZFa+b+c (0.6%). According to statistics, the difference of microdeletion rate between two groups was significant(P < 0.01).</p><p><b>CONCLUSION</b>Y chromosome microdeletions is an important reason of azoospermia. Screening of Y chromosome microdeletions for azoospermia patients before intracytoplasmic sperm injection treatment is essential.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oligospermia
/
Case-Control Studies
/
China
/
Genetic Testing
/
Chromosome Deletion
/
Seminal Plasma Proteins
/
Chromosomes, Human, Y
/
Asian People
/
Diagnosis
/
Azoospermia
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2007
Type:
Article
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