The study on the relationship between Rsa I, Alu I polymorphism of the estrogen receptor beta gene and unknown aetiology hypomenorrhea / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 425-427, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-247302
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between estrogen receptor beta gene (ER beta) polymorphism and unknown aetiology hypomenorrhea in Southwestern China .</p><p><b>METHODS</b>One hundred eumenorrhea women were chosen as control group and another 100 hypomenorrhea patients as case group from Southwestern China. Restriction fragment length polymorphism (RFLP) of the Rsa I and Alu I in ER beta gene was analysed. The ER beta gene polymorphism genotype distribution in case group and control group was compared.</p><p><b>RESULTS</b>R allele frequency in case and control groups was 37.5% and 48.5% respectively, the OR was 0.64 (95%CI 0.42-0.97), P= 0.026. A allele frequency in case and control groups was 18.0% and 11.5% respectively, the OR was 1.69 (95%CI 0.93-3.09), P= 0.07. RFLP of Rsa I and Alu I in both groups were distributed with polymorphism.</p><p><b>CONCLUSION</b>ERbeta gene polymorphism has a relation with unknown aetiological hypomenorrhea. R allele may be the guard factor, and A allele may be its risk factor.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Binding Sites
/
Polymorphism, Restriction Fragment Length
/
Deoxyribonucleases, Type II Site-Specific
/
Polymerase Chain Reaction
/
Genetic Predisposition to Disease
/
Estrogen Receptor beta
/
Gene Frequency
/
Genetics
/
Genotype
Type of study:
Risk factors
Limits:
Adult
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2007
Type:
Article
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