Association of L-selectin gene polymorphism with susceptibility to coronary heart disease / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the possible association between L-selectin gene P213S polymorphism and coronary heart disease (CHD) in Chinese population.</p><p><b>METHODS</b>In total 212 CHD patients diagnosed by angiography and 230 healthy controls were studied. The genotype and allele frequencies of L-selectin gene polymorphism were assayed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).</p><p><b>RESULTS</b>The frequency of the L-selectin gene 213P allele in CHD patients was significantly higher than that in the control group (77.59% vs 69.35%, P=0.006). Compared with the SS genotype, PP homozygote had a significantly increased CHD risk (OR=2.70 and OR=2.15 using unadjusted and adjusted Logistic regression models, respectively). No association was found between the severity of CHD and the Lselectin gene P213S polymorphism</p><p><b>CONCLUSION</b>Our findings suggest that L-selectin gene 213P mutant allele might contribute to susceptibility of Chinese individuals to contract CHD.</p>