Development and Utilization of a Mouse Model of Nasal Polyps
Journal of Rhinology
;
: 1-5, 2015.
Article
in Korean
| WPRIM
| ID: wpr-24737
ABSTRACT
Systemic corticosteroids currently represent the most effective treatment for chronic rhinosinusitis with nasal polyps (CRSwNP), but their long-term use is constrained due to their detrimental side effects. Until recently, development of novel drugs for CRSwNP has been difficult partly due to the absence of a standard animal model of CRSwNP. Exotoxins of Staphylococcus aureus such as staphylococcal enterotoxin B (SEB), are well-known superantigens which can induce a strong immune response; there have been many studies on the association of staphylococcal enterotoxins and development of CRSwNP over the past two decades. Based on previous studies, we invented a mouse model of CRSwNP using SEB. Herein, we explain the protocol development for the mouse model, as well as identify histological and immunological similarities between this mouse model and humans. Furthermore, we describe a study that analyzed the risk factors for CRSwNP such as smoking, and also elaborate on a series of studies that searched for new potential drugs for CRSwNP, including resveratrol, anti-periostin antibody, topical hypoxia-inducible factors, and topical cyclosporine. Based on preceding studies, we have concluded that this mouse model might be a useful tool to investigate the pathophysiology and development of novel drugs for CRSwNP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoke
/
Staphylococcus aureus
/
Smoking
/
Nasal Polyps
/
Risk Factors
/
Cyclosporine
/
Adrenal Cortex Hormones
/
Superantigens
/
Models, Animal
/
Enterotoxins
Type of study:
Etiology study
/
Practice guideline
/
Prognostic study
/
Risk factors
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Journal of Rhinology
Year:
2015
Type:
Article
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