Quick finding of absorption ingredients of Paeoniae Radix Alba by SEMAC / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 687-690, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-247409
ABSTRACT
<p><b>OBJECTIVE</b>To establish a method for quick finding of the absorption ingredients of Paeoniae Radix Alba in order to select the index of quality control.</p><p><b>METHOD</b>The absorption ingredients of three concentration of Paeoniae Radix Alba were investigated with the in vitro-everted intestinal sac (VEIS) model. The intestinal sac fluids of jejunum and ileum were collected in different time and detected by HPLC. The accumulative absorption quantity of albiflorin and paeoniflorin were calculated, respectively.</p><p><b>RESULT</b>Five ingredients could be detected. In different concentrations of Paeoniae Radix Alba, albiflorin and paeoniflorin in various intestinal sections were the linear absorption (R2 > 0.9), conformed to the zero order absorption rate. The values of Ka in the jejunum and ileum were increased along with the raised dosage of the Paeoniae Radix Alba (P < 0.05), indicating a passive absorption manner.</p><p><b>CONCLUSION</b>SEMAC could be used as a tool to find the absorption ingredients of Paeoniae Radix Alba. Compared with the jejunum, the ileum could provide the more absorption information. It was showed that the optimal detecting time was 60 min.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rats, Wistar
/
Paeonia
/
Intestinal Absorption
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS