Flavonoids with special B-ring from Macrothelypteris viridifrons and their anti-proliferative effects on tumor cell / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 582-584, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-247428
ABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents of Macrothelypteris viridifrons and their anti-proliferative effects on tumor cell.</p><p><b>METHOD</b>The compounds were isolated by column chromatography with silica gel, C18 reverse-phase silica gel, sephadex LH-20, and their structures were elucidated on the basis of physiochemical propertities and spectral analysis. The antitumor activities of all compounds were tested with MOLT4, Hep G2, A-549, MCF-7, HT-29, PC-3 tumor cell lines.</p><p><b>RESULT</b>Five compounds were isolated and identified as protoapigenone (1), protoapigenin (2), protoapigenin-4'-O-beta-D-glucopyanoside (3), 5,7-dihydroxy-2-(1,2-isopropyldioxy-4-oxo-cyclohex-5-enyl) -chromen-4-one (4), 5,7-dihydroxy-2-(1-hydroxy-2,6-dimethoxy-cyclohex-4-oxo) -chromen-4-one (5), respectively.</p><p><b>CONCLUSION</b>All compounds were obtained from this plant for the first time. Compounds 1, 4 and 5 showed strong anti-proliferative effects on six tumor cells, which were in concentration-dependent manner.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Flavonoids
/
Chemistry
/
HT29 Cells
/
Ferns
/
Cell Line, Tumor
/
Cell Proliferation
/
Hep G2 Cells
/
Antineoplastic Agents
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article
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