Studies on antitumor activities of triterpene glycoside colochiroside A from sea cucumber Colochirus anceps / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the antitumor activities of the triterpene glycoside colochiroside A (CA) from the sea cucumber Colochirus anceps.</p><p><b>METHOD</b>The tests of antitumor activities in vitro and in vivo were applied to demonstrate the effect of CA.</p><p><b>RESULT</b>The preliminary cytotoxic assay of CA exhibited significant cytotoxic activity against 6 types cultured tumor cell lines of p388, HL60, A-549, SpC-A4, MKN-28, and SGC-7901, the mean of IC50 were (3.61 +/- 0.55) mg x L(-1). The preliminary antitumor assay of CA indicated that this saponin exhibited high inhibiting activity against the H22 live cancer and the S180 sarcoma cells in mouse. The inhibition ratio to H22 liver cancer were 34.8%, 43.9% and 52.2%, while the ratio to S180 sarcoma were 36.4%, 70.0%, the immunoregulatory founction study indicated CA has not significant effect on the developments of thymus and spleen.</p><p><b>CONCLUSION</b>The saponin CA exhibited remarkable antineoplastic activities in vitro and in vivo, and could not reduce the immunoregulatory founction of mice.</p>