Preparation and properties of sustained-release pellets of active components from Ligusticun chuanxiong / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 439-442, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-247463
ABSTRACT
<p><b>OBJECTIVE</b>To prepare sustained-release pellets of active components from Ligusticun chuanxiong by coating in the fluid-bed.</p><p><b>METHOD</b>The fast-release pellets were prepared by the extrusion-spheronization process. The coating formulation was optimized with the release of ferulic acid as criteria. The micromeritic properties and drug dissolution behaviors of the prepared pellets were evaluated.</p><p><b>RESULT</b>The pellets presented perfect sphericity. The obviously sustained-release effects were shown in 12 h. The coating weight gain was the major factor impacting drug release.</p><p><b>CONCLUSION</b>The coating pellets show the obviously sustained-release effects.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chemistry
/
Technology, Pharmaceutical
/
Coumaric Acids
/
Ligusticum
/
Delayed-Action Preparations
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article
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