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Preparation and properties of sustained-release pellets of active components from Ligusticun chuanxiong / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 439-442, 2011.
Article in Chinese | WPRIM | ID: wpr-247463
ABSTRACT
<p><b>OBJECTIVE</b>To prepare sustained-release pellets of active components from Ligusticun chuanxiong by coating in the fluid-bed.</p><p><b>METHOD</b>The fast-release pellets were prepared by the extrusion-spheronization process. The coating formulation was optimized with the release of ferulic acid as criteria. The micromeritic properties and drug dissolution behaviors of the prepared pellets were evaluated.</p><p><b>RESULT</b>The pellets presented perfect sphericity. The obviously sustained-release effects were shown in 12 h. The coating weight gain was the major factor impacting drug release.</p><p><b>CONCLUSION</b>The coating pellets show the obviously sustained-release effects.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Chemistry / Technology, Pharmaceutical / Coumaric Acids / Ligusticum / Delayed-Action Preparations Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Chemistry / Technology, Pharmaceutical / Coumaric Acids / Ligusticum / Delayed-Action Preparations Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article